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Invitrogen™ PAPPA2 Polyclonal Antibody
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Catalog No. PIPA553793
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100 μL
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PIPA553793 100 μL
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Catalog No. PIPA553793 Supplier Invitrogen™ Supplier No. PA553793
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: NPAGLRGAVE EPAAPWVGDS PIGQSELLGD DDAYLGNQRS KESLGEAGIQ KGSAMAATTT TAIFTTLNEP KPETQRRGWA KSRQRRQVWK RRAEDGQGDS GISSHFQPWP KH Highest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 54%.

PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PAPPA2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PAPPA2
Gene Accession No. Q9BXP8
Gene Alias LOC680415; PAPPA2; PAPP-A2; pappalysin 2; pappalysin-2; Pappe; PAPP-E; PLAC3; placenta-specific 3; pregnancy-associated plasma preproprotein-A2; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1; pregnancy-associated plasma protein-E; RP4-774I24.1; similar to pappalysin 2 isoform 1
Gene Symbols PAPPA2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PAPPA2. Recombinant protein control fragment (Product #RP-91867).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60676
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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