Invitrogen™ PAPPA2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521046

Catalog No. PIPA521046

Description

A suggested positive control is Hela cell lysate. PA5-21046 can be used with blocking peptide PEP-1160.

PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.

Specifications

• Antigen: PAPPA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PAPPA2
• Gene Alias: LOC680415; PAPPA2; PAPP-A2; pappalysin 2; pappalysin-2; Pappe; PAPP-E; PLAC3; placenta-specific 3; pregnancy-associated plasma preproprotein-A2; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1; pregnancy-associated plasma protein-E; RP4-774I24.1; similar to pappalysin 2 isoform 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23850, 60676, 680415
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9BXP8
• Gene Symbols: PAPPA2
• Immunogen: A 15 amino acid peptide near the amino terminus of human PLAC3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG