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PARL Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501735423 Shop All Proteintech Group Inc Products
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50-173-5423 150 μL
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Catalog No. 50-173-5423 Supplier Proteintech Group Inc Supplier No. 266791AP150UL
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Description

Rabbit Polyclonal Antibody

PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals. In lymphocytes and neurons, PARL′s association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis. Variations in this gene have been associated with increased risk for type 2 diabetes. PARL may also play a role in the progression of Alzheimer′s disease through its associations with presenilin-1 and -2. Multiple isoforms of PARL are known to exist.

Specifications

Antigen PARL
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.47 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene PARL
Gene Accession No. Q9H300
Gene Alias PARL, Pbeta, PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
Gene Symbols PARL
Host Species Rabbit
Immunogen PARL Fusion Protein Ag24789
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55486
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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