Invitrogen™ PARN Monoclonal Antibody (11D8)

Catalog No.	Quantity
PIMA549199	100 μg

Catalog No. PIMA549199 Supplier Invitrogen™ Supplier No. MA549199

Description

Mouse Monoclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human 293T whole cell, monkey COS-7 whole cell, human CACO-2 whole cell, rat kidney tissue, rat C6 whole cell, mouse NIH/3T3 whole cell. IHC: human mammary cancer tissue. ICC/IF: A549 cell, U251 cell. Flow: A549 cell, A431 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PARN
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 11D8
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene: Parn
• Gene Accession No.: O95453, Q8VDG3
• Gene Alias: 1200003I18Rik; DAN; Deadenylating nuclease; deadenylation nuclease; DKCB6; Parn; PFBMFT4; poly(A)-specific ribonuclease; poly(A)-specific ribonuclease (deadenylation nuclease); poly(A)-specific ribonuclease PARN; Polyadenylate-specific ribonuclease; RGD1565449
• Gene Symbols: Parn
• Host Species: Mouse
• Immunogen: E. coli-derived human PARN recombinant protein (Position: M1-Y301).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 360464, 5073, 74108
• Target Species: Human, Mouse, Monkey, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2b