Invitrogen™ PARN Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552893

Catalog No. PIPA552893

Description

Immunogen sequence: QEELNDAVGF SRVIHAIANS GKLVIGHNML LDVMHTVHQF YCPLPADLSE FKEMTTCVFP RLLDTKLMAS TQPFKDIINN TSLAELEKRL KETPFNPPKV ESAEGFPSYD Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PARN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Parn
• Gene Alias: 1200003I18Rik; DAN; Deadenylating nuclease; deadenylation nuclease; DKCB6; Parn; PFBMFT4; poly(A)-specific ribonuclease; poly(A)-specific ribonuclease (deadenylation nuclease); poly(A)-specific ribonuclease PARN; Polyadenylate-specific ribonuclease; RGD1565449
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 360464, 5073, 74108
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O95453, Q8VDG3
• Gene Symbols: Parn
• Immunogen: Recombinant protein corresponding to Human PARN. Recombinant protein control fragment (Product #RP-89280).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG