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Invitrogen™ PARN Polyclonal Antibody
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Catalog No. PIPA579783
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PIPA579783 100 μg
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Catalog No. PIPA579783 Supplier Invitrogen™ Supplier No. PA579783
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human placenta tissue, human COLO-320 whole cell, human HepG2 whole cell, human PANC-1 whole cell, human SGC-7901 whole cell, human MDA-MB-231 whole cell, rat kidney tissue, mouse heart tissue, mouse kidney tissue. IHC: human mammary cancer tissue, mouse small intestine tissue, rat small intestine tissue. ICC/IF: A549 cell. Flow: A431 cell.

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PARN
Applications ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and 0.05mg sodium azide
Gene Parn
Gene Accession No. O95453, Q8VDG3
Gene Alias 1200003I18Rik; DAN; Deadenylating nuclease; deadenylation nuclease; DKCB6; Parn; PFBMFT4; poly(A)-specific ribonuclease; poly(A)-specific ribonuclease (deadenylation nuclease); poly(A)-specific ribonuclease PARN; Polyadenylate-specific ribonuclease; RGD1565449
Gene Symbols Parn
Host Species Rabbit
Immunogen E. coli-derived human PARN recombinant protein (Position: M1-Y301).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 360464, 5073, 74108
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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