Invitrogen™ Parvalbumin Monoclonal Antibody (C12), APC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545927

Catalog No. PIMA545927

Description

A 1:500 dilution of MA5-45927 was sufficient for detection of Parvalbumin in 15 μg of Rat Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects 12 kDa.

Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.

Specifications

• Antigen: Parvalbumin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
• Gene Accession No.: P02625, P20472, P32848
• Gene Symbols: Pvalb
• Immunogen: Synthetic peptide from the full length Rat Parvalbumin protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: C12
• Conjugate: APC
• Gene: Pvalb
• Gene Alias: D22S749; HGNC:9704; MGC116759; PALB1; Parv; parvalbumin; Parvalbumin (calcium binding protein); parvalbumin alpha; PV; Pva; PVALB
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 19293, 25269, 5816
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov