Patched1 Monoclonal Antibody (OTI1H10), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA803741

Catalog No. 50-167-9904

Description

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Specifications

• Antigen: Patched1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q13635
• Gene Symbols: PTCH1
• Immunogen: Human recombit protein fragment corresponding to amino acids 770-1027 of human PTCH1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1H10
• Conjugate: Unconjugated
• Gene: PTCH1
• Gene Alias: BCNS, NBCCS, PTC, PTC1, PTCH
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5727
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid