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PATZ1 Mouse anti-Human, Clone: OTI2D2, lyophilized, TrueMAB™
SDP

Catalog No. 501669377
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50-166-9377 100 μg
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Catalog No. 50-166-9377 Supplier OriGene Supplier No. CF809258
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

Specifications

Antigen PATZ1
Applications Western Blot
Classification Monoclonal
Clone OTI2D2
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene PATZ1
Gene Accession No. Q9HBE1
Gene Alias MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23
Gene Symbols PATZ1
Host Species Mouse
Immunogen Full length human recombit protein of human PATZ1 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23598
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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