PATZ1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA530478

Catalog No. PIPA530478

Description

Recommended positive controls: A549, HeLa, HepG2, HCT116. Predicted reactivity: Mouse (99%), Rat (99%), Rabbit (99%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36. 1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

Specifications

• Antigen: PATZ1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PATZ1
• Gene Alias: 8430401L15Rik; AI447519; BTB/POZ domain zinc finger transcription factor; BTB-POZ domain zinc finger transcription factor; dJ400N23; Mazr; MAZ-related factor; Patz; PATZ1; POZ (BTB) and AT hook containing zinc finger 1; POZ-, AT hook-, and zinc finger-containing protein 1; POZ/BTB and AT hook containing zinc finger 1; POZ-AT hook-zinc finger protein; protein kinase A RI subunit alpha-associated protein; RIAZ; transcription factor (MAZ-related) MAZR; ZBTB19; Zfp278; zi; Zinc finger and BTB domain-containing protein 19; zinc finger protein 278; Zinc finger sarcoma gene protein; ZNF278; ZSG
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23598
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.72 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9HBE1
• Gene Symbols: PATZ1
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 194 of Human PATZ1
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov