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PATZ1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 262251AP150UL

Encompass_Preferred

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Catalog No. 50-173-5263


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Description

Description

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
Specifications

Specifications

PATZ1
Polyclonal
Unconjugated
PATZ1
dJ400N23, MAZR, PATZ, PATZ1, RIAZ, ZBTB19, Zinc finger protein 278, ZNF278, ZSG
Rabbit
Antigen Affinity Chromatography
RUO
23598, 56218
-20°C
Liquid
Western Blot
0.53 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9HBE1
Patz1
PATZ1 Fusion Protein Ag23912
150 μL
Primary
Human, Mouse
Antibody
IgG
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