PAX5 Mouse anti-Human, Clone: 7D3, Abnova™

Catalog No.	Quantity
89-934-729	50 μg

Catalog No. 89-934-729 Supplier Abnova Corporation Supplier No. MAB12848

Description

Mouse monoclonal antibody raised against partial recombinant human PAX5.

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq]

Specifications

• Antigen: PAX5
• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Monoclonal
• Clone: 7D3
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant human PAX5.
• Dilution: ELISA (1:10000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.5% protein stabilizer, 0.05% sodium azide).
• Gene Alias: BSAP
• Gene Symbols: PAX5
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 235-382 of human PAX5.
• Purification Method: Protein G purification
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5079
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1