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Pax6 Antibody (PAX6/1166), Novus Biologicals™
SDP

Catalog No. p-5540095 Shop All R&D Systems Products
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NBP24457600 0.02 mg
NBP24457601 0.1 mg
NBP24457602 0.2 mg
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Catalog No. NBP24457600 Supplier Novus Biologicals Supplier No. NBP2445760.02MG
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Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

Pax6 Monoclonal specifically detects Pax6 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Flow (Intracellular), Knockout Validated.

Specifications

Antigen Pax6
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone PAX6/1166
Concentration 0.2mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Accession No. P26367
Gene Alias keratitis), MGC17209, Oculorhombin, paired box 6, paired box protein Pax-6
Gene Symbols PAX6
Host Species Mouse
Immunogen Recombinant fragment (N-terminus; aa 1-300) of human PAX6 protein
Molecular Weight of Antigen 47 kDa
Purification Method Protein A or G purified
Quantity 0.02 mg
Regulatory Status RUO
Research Discipline Cellular Markers, Diabetes Research, Neuronal Stem Cell Markers, Neuronal Stem Cells, Neuroscience, Sensory Systems, Stem Cell Markers, Stem Cells, Transcription Factors and Regulators, Vision
Primary or Secondary Primary
Gene ID (Entrez) 5080
Test Specificity Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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