Pax6 Antibody (PAX6/498) - IHC-Prediluted, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP248226

Catalog No. NBP248226

Description

Pax6 Monoclonal specifically detects Pax6 in Human, Mouse, Rat, Chicken samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Pax6
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Symbols: PAX6
• Immunogen: Recombinant fragment (N-terminus; aa 1-300) of human PAX6 protein
• Quantity: 7 mL
• Research Discipline: Cellular Markers, Diabetes Research, Neuronal Stem Cell Markers, Neuronal Stem Cells, Neuroscience, Sensory Systems, Stem Cell Markers, Stem Cells, Transcription Factors and Regulators, Vision
• Gene ID (Entrez): 5080
• Target Species: Human, Mouse, Rat, Chicken
• Form: Purified

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
• Clone: PAX6/498
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Alias: keratitis), MGC17209, Oculorhombin, paired box 6, paired box protein Pax-6
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
• Content And Storage: Store at 4C.
• Isotype: IgG1 κ