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PAX8 Antibody (PAX8/1491), DyLight 488, Novus Biologicals™
SDP

Catalog No. NBP254486G Shop All R&D Systems Products
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Catalog No. NBP254486G Supplier Novus Biologicals Supplier No. NBP254486G
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Description

Mouse Monoclonal Antibody

PAX8 Monoclonal specifically detects PAX8 in Human samples. It is validated for Western Blot, Immunohistochemistry-Paraffin.

Specifications

Antigen PAX8
Applications Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone PAX8/1491
Conjugate DyLight 488
Dilution Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias paired box 8, paired box gene 8, paired box protein Pax-8, paired domain gene 8
Gene Symbols PAX8
Host Species Mouse
Immunogen Recombinant fragment (around aa 60-261) of human PAX8 protein (exact sequence is proprietary) (Uniprot: Q06710)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cancer
Primary or Secondary Primary
Gene ID (Entrez) 7849.0
Test Specificity Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG2b κ
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