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PAX8 Rabbit anti-Human, CoraLite 488, Polyclonal, Proteintech
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Catalog No. 502256760 Shop All Proteintech Group Inc Products
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50-225-6760 100 μL
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Catalog No. 50-225-6760 Supplier Proteintech Group Inc Supplier No. CL48810336100UL
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Description

Rabbit Polyclonal Antibody

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. This antibody can detect all 5 isoforms of PAX8 (31 kDa, 34 kDa, 41 kDa, 43 kDa and 48 kDa). A 58-60 kDa form has also been reported (PMID:15650356, 1049952). Proteintech's 10336-1-AP antibody has cross-reactivities with the other PAX family members.

Specifications

Antigen PAX8
Applications Immunofluorescence
Classification Polyclonal
Concentration 1000 μg/mL
Conjugate CoraLite 488
Host Species Rabbit
Quantity 100 μL
Primary or Secondary Primary
Gene ID (Entrez) 7849
Target Species Human
Form Liquid
Isotype IgG
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