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Invitrogen™ PBRM1 Polyclonal Antibody
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Catalog No. PIPA584414
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100 μL
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PIPA584414 100 μL
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Catalog No. PIPA584414 Supplier Invitrogen™ Supplier No. PA584414
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PVIQQPTTPM FVAPPPKTQR LLHSEAYLKY IEGLSAESNS ISKWDQTLAA RRRDVHLSKE QESRLPSHWL KSKGAHTTMA DALWRLRDLM LRDTLNIR Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 100%.

The PBRM1 gene encodes a subunit of the PBAF (Polybromo-associated BAF) chromatin remodeling complex, playing a crucial role in the regulation of chromatin structure and transcription. PBRM1, also known as BAF180, contains bromodomains that recognize acetylated lysine residues on histone tails, facilitating chromatin remodeling necessary for effective transcriptional regulation. This gene is frequently mutated in renal cell carcinoma, particularly clear cell renal cell carcinoma (ccRCC), where such mutations are implicated in the pathogenesis of the disease. PBRM1 acts as a tumor suppressor, and its loss of function can lead to deregulation of gene expression, contributing to oncogenic processes. It is involved in pathways that govern cell cycle regulation and DNA damage response, reflecting its importance in maintaining genomic stability. Ongoing research focuses on understanding PBRM1's interactions within chromatin remodeling complexes and its potential as a therapeutic target in cancer treatment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PBRM1
Applications ChIP Assay, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Pbrm1
Gene Accession No. Q86U86
Gene Alias 2310032M22Rik; 2610016F04Rik; AI507524; BAF180; BRG1-associated factor 180; glutamate receptor interacting protein 2; hPB1; LOC506557 protein; PB1; PBRM1; polybromo 1; polybromo-1D; Protein polybromo-1; RGD1565549
Gene Symbols Pbrm1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PBRM1. Recombinant protein control fragment (Product #RP-105128).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55193
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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