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Invitrogen™ PBRM1 Polyclonal Antibody
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Catalog No. PIPA541591
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100 μL
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PIPA541591 100 μL
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Catalog No. PIPA541591 Supplier Invitrogen™ Supplier No. PA541591
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Description

Rabbit Polyclonal Antibody

Peptide sequence: PSRKRRRLSN LPTVDPIAVC HELYNTIRDY KDEQGRLLCE LFIRAPKRRN Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%.

The PBRM1 gene encodes a subunit of the PBAF (Polybromo-associated BAF) chromatin remodeling complex, playing a crucial role in the regulation of chromatin structure and transcription. PBRM1, also known as BAF180, contains bromodomains that recognize acetylated lysine residues on histone tails, facilitating chromatin remodeling necessary for effective transcriptional regulation. This gene is frequently mutated in renal cell carcinoma, particularly clear cell renal cell carcinoma (ccRCC), where such mutations are implicated in the pathogenesis of the disease. PBRM1 acts as a tumor suppressor, and its loss of function can lead to deregulation of gene expression, contributing to oncogenic processes. It is involved in pathways that govern cell cycle regulation and DNA damage response, reflecting its importance in maintaining genomic stability. Ongoing research focuses on understanding PBRM1's interactions within chromatin remodeling complexes and its potential as a therapeutic target in cancer treatment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PBRM1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene Pbrm1
Gene Accession No. Q86U86
Gene Alias 2310032M22Rik; 2610016F04Rik; AI507524; BAF180; BRG1-associated factor 180; glutamate receptor interacting protein 2; hPB1; LOC506557 protein; PB1; PBRM1; polybromo 1; polybromo-1D; Protein polybromo-1; RGD1565549
Gene Symbols Pbrm1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human PBRM1 (aa 31-80).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55193
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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