Invitrogen™ PC1/3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA579787

Catalog No. PIPA579787

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Rat Liver Tissue, Rat Thymus Tissue, A549 Cell, HELA Cell, COLO320 Cell, PANC Cell. IHC: rat intestine tissue.

PCSK1 (Proprotein Convertase, Subtilisin/Kexin-Type, 1), also known as PC1 or NEC1, is an enzyme that in humans is encoded by the PCSK1 gene. Proprotein convertase-1 is a neuroendocrine convertase that belongs to a family of subtilisin-like serine endoproteases that process large precursor proteins into mature bioactive products. By in situ hybridization, Seidah et al. (1991) mapped the NEC1 gene to human chromosome 5q15-q21 and mouse chromosome 13. Ohagi et al. (1996) noted that PC1 initiates the sequential processing of proinsulin to insulin by cleaving the proinsulin molecule on the C-terminal side of the dibasic peptide, arg31-arg32, joining the B-chain and C-peptide. By observing the phenotypic features in patients with PC1 mutations, Jackson et al. (2003) concluded that human intestinal absorptive function is dependent on PC1 activity.

Specifications

• Antigen: PC1/3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCSK1
• Gene Alias: Att-1; BDP; BMIQ12; furin homolog; NEC 1; Nec1; Nec-1; Neuroendocrine convertase 1; PC1; PC3; PCSK1; Phpp-1; Prohormone convertase 1; prohormone convertase 1/3; prohormone convertase 3; propeptide-processing protease; Proprotein convertase 1; proprotein convertase subtilisin/kexin type 1; Protein convertase subtilisin / kexin type I; Protein convertase subtilisin / kexin, type I; SPC3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18548, 25204, 5122
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene Accession No.: P28840, P29120, P63239
• Gene Symbols: PCSK1
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human PC1/3 (726-740aa DVFYNTKPYKHRDDR).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov