Pc2 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc IHC00668T

Catalog No. 50-157-2504

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Rabbit, Guinea pig_10141, Pig, Panda, Monkey, Gorilla, Chimpanzee, Gray short

CBX4 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintece of proper expression patterns of developmental master regulators; changes in expression pf PcG proteins have been associated with cancer. CBX4 is a part of the cellular memory system responsible for the inheritance of gene activity by progeny cells. It participates in maintaining the transcriptionally repressive state of genes. CBX4 is part of acomplex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ′Lys-119′, rendering chromatin heritably changed in its expressibility. CBX4 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I.

Specifications

• Antigen: Pc2
• Classification: Polyclonal
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Accession No.: O00257, O55187
• Gene Symbols: Cbx4
• Immunogen: Between 150 and 200
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry
• Conjugate: Unconjugated
• Gene: CBX4
• Gene Alias: E3 SUMO-protein ligase CBX4; Chromobox protein homolog 4; Polycomb 2 homolog; Pc2; hPc2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12418, 8535
• Content And Storage: 4° C
• Form: Liquid