Invitrogen™ PCAF Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565981

Catalog No. PIPA565981

Description

Immunogen sequence: KFSHLPAKERQ TIVELAKMFL NRINYWHLEA PSQRRLRSPN DDISGYKENY Highest antigen sequence identity to the following orthologs - mouse 94%, rat 59%.

PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.

Specifications

• Antigen: PCAF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KAT2B
• Gene Alias: A930006P13Rik; AI461839; AW536563; CAF; CREBBP-associated factor; histone acetylase PCAF; Histone acetyltransferase KAT2B; histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; Kat2b; Lysine acetyltransferase 2B; P/ PCAF; P/CAF; P300/CBP-associated factor; Pcaf; Spermidine acetyltransferase KAT2B
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8850
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q92831
• Gene Symbols: KAT2B
• Immunogen: Recombinant Human PCAF. Recombinant protein control fragment (Product #RP-106669).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG