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Invitrogen™ PCAF Recombinant Rabbit Monoclonal Antibody (JU88-63)
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Catalog No. PIMA542478
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100 μL
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PIMA542478 100 μL
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Catalog No. PIMA542478 Supplier Invitrogen™ Supplier No. MA542478
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: Rat kidney tissue lysate, K562, Hela. Subcellular Location: Nucleus.

PCAF (histone acetyltransferase KAT2B) functions as a histone acetyltransferase (HAT) to promote transcriptional activation. It has significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. PCAF also acetylates non-histone proteins such as ACLY, PLK4, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. PCAF also acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. It is involved in heart and limb development by mediating acetylation of TBX5 and acetylation regulating nucleocytoplasmic shutting of TBX5.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PCAF
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone JU88-63
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 40% glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene KAT2B
Gene Accession No. Q92831, Q9JHD1
Gene Alias A930006P13Rik; AI461839; AW536563; CAF; CREBBP-associated factor; histone acetylase PCAF; Histone acetyltransferase KAT2B; histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; Kat2b; Lysine acetyltransferase 2B; P/ PCAF; P/CAF; P300/CBP-associated factor; Pcaf; Spermidine acetyltransferase KAT2B
Gene Symbols KAT2B
Host Species Rabbit
Immunogen Synthetic peptide within Human PCAF aa 121-211 .
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18519, 301164, 8850
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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