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Invitrogen™ PCBP1 Monoclonal Antibody (A3E10)
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Catalog No. PIMA542531
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100 μL
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PIMA542531 100 μL
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Catalog No. PIMA542531 Supplier Invitrogen™ Supplier No. MA542531
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Description

Mouse Monoclonal Antibody

Positive Control: Hela cell lysate, K562 cell lysate, Human colon cancer tissue. Subcellular Location: Cytoplasm, Nucleus.

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular polydomains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PCBP1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone A3E10
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene PCBP1
Gene Accession No. P60335, Q15365
Gene Alias [a]CP-1; Alpha-CP1; alphaCP-1; epididymis secretory protein Li 85; HEL-S-85; Heterogeneous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein X; hnRNP E1; hnRNP-E1; hnRNP-E1 protein; hnRNP-X; HNRPE1; HNRPX; Nucleic acid-binding protein SUB2.3; PCBP1; poly(rC) binding protein 1; poly(rC)-binding protein 1; RGD1561319; WBP17
Gene Symbols PCBP1
Host Species Mouse
Immunogen Recombinant protein within human PCBP1 aa 1-356.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23983, 5093
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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