Invitrogen™ PCBP1 Recombinant Rabbit Monoclonal Antibody (7Y8C5)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA551448

Catalog No. FEMA551448

Description

Immunogen sequence: LRLVVPATQC GSLIGKGGCK IKEIRESTGA QVQVAGDMLP NSTERAITIA GVPQSVTECV KQICLVMLET LSQSPQGRVM TIPYQPMPAS SPVICAGGQD R.

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular polydomains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Specifications

• Antigen: PCBP1
• Classification: Recombinant Monoclonal
• Concentration: 0.087 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P60335, Q15365
• Gene Symbols: PCBP1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human hnRNP E1/PCBP1 (NP_006187.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Format: Liquid

• Applications: ELISA, Western Blot
• Clone: 7Y8C5
• Conjugate: Unconjugated
• Gene: PCBP1
• Gene Alias: [a]CP-1; Alpha-CP1; alphaCP-1; epididymis secretory protein Li 85; HEL-S-85; Heterogeneous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein X; hnRNP E1; hnRNP-E1; hnRNP-E1 protein; hnRNP-X; HNRPE1; HNRPX; Nucleic acid-binding protein SUB2.3; PCBP1; poly(rC) binding protein 1; poly(rC)-binding protein 1; RGD1561319; WBP17
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23983, 5093
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Isotype: IgG