Invitrogen™ PCBP1 Recombinant Rabbit Monoclonal Antibody (7M1K0)

Catalog No.	Quantity
PIMA537903	100 μL

Catalog No. PIMA537903

Supplier: Invitrogen™ MA537903

Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: HeLa, HepG2, A-431, K-562, Mouse lung, Mouse brain, Rat pancreas Immunogen sequence: MDAGVTESGL NVTLTIRLLM HGKEVGSIIG KKGESVKRIR EESGARINIS EGNCPERIIT LTGPTNAIFK AFAMIIDKLE EDINSSMTNS TAASRPPVTL.

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular polydomains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Specifications

• Antigen: PCBP1
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 7M1K0
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: PCBP1
• Gene Accession No.: P60335, Q15365
• Gene Alias: [a]CP-1; Alpha-CP1; alphaCP-1; epididymis secretory protein Li 85; HEL-S-85; Heterogeneous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein E1; heterogenous nuclear ribonucleoprotein X; hnRNP E1; hnRNP-E1; hnRNP-E1 protein; hnRNP-X; HNRPE1; HNRPX; Nucleic acid-binding protein SUB2.3; PCBP1; poly(rC) binding protein 1; poly(rC)-binding protein 1; RGD1561319; WBP17
• Gene Symbols: PCBP1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PCBP1 (Q15365).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23983, 500242, 5093
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG