Invitrogen™ PCBP2 Monoclonal Antibody (4B9C7)

Catalog No.	Quantity
PIMA549224	100 μg

Catalog No. PIMA549224 Supplier Invitrogen™ Supplier No. MA549224

Description

Mouse Monoclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human T-47D whole cell, human HL-60 whole cell, human A549 whole cell, human HepG2 whole cell, rat brain tissue, mouse brain tissue. ICC/IF: Caco-2 cell. Flow: PC-3 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PCBP2
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 4B9C7
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and no preservative
• Gene: PCBP2
• Gene Accession No.: Q15366, Q61990
• Gene Alias: Alpha CP2; Alpha-CP2; alphaCP-2; AW412548; CBP; CTBP; fb36h02; Heterogeneous nuclear ribonucleoprotein E2; heterogeneous nuclear ribonucleoprotein X; heterogenous nuclear ribonucleoprotein E2; hnRNP E2; hnRNP X; HNRNPE2; hnRNP-E2; Hnrnpx; HNRPE2; Hnrpx; MGC110998; Pcbp2; pcbp2 protein; PCBP3; poly(rC) binding protein 2; poly(rC)-binding protein 2; Putative heterogeneous nuclear ribonucleoprotein X; rCbinding protein 2; wu:fb36h02; zgc:55964
• Gene Symbols: PCBP2
• Host Species: Mouse
• Immunogen: E.coli-derived human PCBP2/hnRNP E2 recombinant protein (Position: Q197-K276).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18521, 363005, 5094
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2a