Invitrogen™ PCBP4 Polyclonal Antibody

Catalog No.	Quantity
PA550704	100 μL

Catalog No. PA550704 Supplier Invitrogen™ Supplier No. PA550704

Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total MCG10 protein.

MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.

Specifications

• Antigen: PCBP4
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1.9 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: PCBP4
• Gene Accession No.: P57723, P57724
• Gene Alias: 1200003L19Rik; alpha CP-4; alpha-CP4; AlphaCP-4; alphaCP-4 protein; CBP; LIP4; LYST-interacting protein; MCG10; Pcbp4; poly(rC) binding protein 4; poly(rC)-binding protein 4; RNA binding protein MCG10
• Gene Symbols: PCBP4
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues near the C terminal of human poly(rC) binding protein 4.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 57060, 59092
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG