Invitrogen™ PCDH12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520703

Catalog No. PIPA520703

Description

A suggested positive control is K562 cell lysate. PA5-20703 can be used with blocking peptide PEP-0818.

Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2, 289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling.

Specifications

• Antigen: PCDH12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCDH12
• Gene Alias: Pcdh12; Pcdh14; protocadherin 12; protocadherin 14; protocadherin-12; Protocadherin-12, secreted form; UNQ395/PRO731; Vascular cadherin-2; vascular endothelial cadherin 2; vascular endothelial cadherin-2; VECAD2; VE-cad-2; VE-cadherin 2; VE-cadherin-2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116808, 51294, 53601
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O55134, Q9NPG4
• Gene Symbols: PCDH12
• Immunogen: A 17 amino acid peptide near the amino terminus of human PCDH12.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov