Invitrogen™ PCDHA10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA543335

Catalog No. PIPA543335

Description

Peptide sequence: ESRLLDSRFP LEGASDADVG ENALLTYKLS PNEYFVLDII NKKDKDKFPV Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Specifications

• Antigen: PCDHA10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCDHA10
• Gene Alias: cadherin-related neuronal receptor 10; cadherin-related neuronal receptor 3; Cnr3; CNR8; CNRN8; CNRS8; Crnr3; CRNR8; KIAA0345-like 4; ortholog to mouse CNR8; Pcdha10; Pcdha14; PCDH-ALPHA10; PCDH-alpha-10; protocadherin alpha 10; protocadherin alpha 14; protocadherin alpha-10; rCNRv10
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 56139
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9Y5I2
• Gene Symbols: PCDHA10
• Immunogen: Synthetic peptide directed towards the N-terminal of human PCDHA10 (aa 143-192).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG