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PCDHAC2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550724

Catalog No. PA550724


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Description

Description

The antibody detects endogenous levels of total PCDHAC2 protein.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Specifications

Specifications

PCDHAC2
Polyclonal
Unconjugated
PCDHAC2
Liquid
PCDHAC2
Synthetic peptide corresponding to a region derived from internal residues of human protocadherin alpha subfamily C, 2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
2.9 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9Y5I4
PCDH-ALPHA-C2
Rabbit
IgG
100 μL
-20°C
Primary
56134
Documents
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