Invitrogen™ PCDHGA2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552603

Catalog No. PIPA552603

Description

Immunogen sequence: PNTDWRFSQA QRPGTSGSQN GDDTGTWPNN QFDTEMLQAM ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 89%.

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Specifications

• Antigen: PCDHGA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCDHGA2
• Gene Alias: mKIAA0588; Pcdhga2; PCDH-GAMMA-A2; protocadherin gamma subfamily A, 2; protocadherin gamma-A2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 498846, 56113, 93710
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y5H1
• Gene Symbols: PCDHGA2
• Immunogen: Recombinant protein corresponding to Human PCDHGA1. Recombinant protein control fragment (Product #RP-104307).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG