Invitrogen™ PCDHGA8 Monoclonal Antibody (1C11)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA520814

Catalog No. PIMA520814

Description

Peptide Sequence: LENSLPGTVI AFLSVHDQDS GKNGQVVCYT RDNLPFKLEK SIGNYYRLVT RKYLDRENVS IYNITVMASD LGTPPLSTET QIALHVAD.

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Specifications

• Antigen: PCDHGA8
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9Y5G5
• Gene Symbols: PCDHGA8
• Immunogen: PCDHGA8 (NP_114477, 357 a.a. ~ 444 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot
• Clone: 1C11
• Conjugate: Unconjugated
• Gene: PCDHGA8
• Gene Alias: KIAA0327; PCDHGA8; PCDH-gamma-A8; protocadherin gamma subfamily A, 8; protocadherin gamma-A8
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9708
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid