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Invitrogen™ PCGF1 Polyclonal Antibody
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Catalog No. PIPA552822
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100 μL
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PIPA552822 100 μL
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Catalog No. PIPA552822 Supplier Invitrogen™ Supplier No. PA552822
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LVPGLQDSEE KRIREFYQSR GLDRVTQPTG EEPALSNLGL PFSSFDHSKA HYYRYDEQLN LCLERLSSGK DKNKSVLQNK YVRCSVRAEV RHLRRVLCHR LMLNPQHVQL LFDNEVLPDH MTMKQIWLSR WFGKPSPLLL QYSVK Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PCGF1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PCGF1
Gene Accession No. Q9BSM1
Gene Alias 2010002K04Rik; AU024121; nervous system polycomb 1; nervous system Polycomb-1; Nspc1; Pcgf1; polycomb group ring finger 1; polycomb group RING finger protein 1; RING finger protein 68; RNF3A-2; RNF68
Gene Symbols PCGF1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PCGF1. Recombinant protein control fragment (Product #RP-89474).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84759
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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