Invitrogen™ PCGF5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5140096

Catalog No. PIPA5140096

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: DVLCNGEIMG KDHTMEFIYM TRWRLRGENF RCLNCSASQV CSQDGPLYQS YPMVLQYRPR ID.

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. [UniProt].

Specifications

• Antigen: PCGF5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCGF5
• Gene Alias: 0610009F02Rik; 1110054A01Rik; 5830406C17Rik; 5830443C21Rik; 9530023M17Rik; AI324127; Pcgf5; polycomb group ring finger 5; polycomb group RING finger protein 5; polycomb group RING finger protein 5-like protein; ring finger protein (C3HC4 type) 159; RING finger protein 159; Rnf159
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84333
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q86SE9
• Gene Symbols: PCGF5
• Immunogen: Recombinant protein corresponding to Human PCGF5. Recombinant protein control fragment (Product #RP-108965).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG