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Invitrogen™ PCGF6 Polyclonal Antibody
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Catalog No. PIPA576818
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100 μL
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PIPA576818 100 μL
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Catalog No. PIPA576818 Supplier Invitrogen™ Supplier No. PA576818
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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes. Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation. PCGF6 (polycomb group ring finger 6), also known as MBLR or RNF134, is a 350 amino acid nuclear protein that is ubiquitously expressed and contains one RING-type zinc finger. PCGF6 acts as a transcriptional repressor and regulates the level of histone H3K4Me3 by activating SmcY histone demethylase. PCGF6 exists as two alternatively spliced isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PCGF6
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene PCGF6
Gene Accession No. Q5XI70, Q99NA9, Q9BYE7
Gene Alias 4933407A11Rik; AI604840; Mblr; Mel18 and Bmi1-like RING finger; Mel18- and Bmi1-like RING finger protein; Mel18 and Bmi1-like RING finger protein; Pcgf6; polycomb group ring finger 6; polycomb group RING finger protein 6; RING finger protein 134; RNF134
Gene Symbols PCGF6
Host Species Rabbit
Immunogen Recombinant full length Human PCGF6.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 309457, 71041, 84108
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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