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PCL2 Monoclonal Antibody (3A9), Active Motif™
SDP

Catalog No. 501993191
Encompass
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50-199-3191 10 μg
50-199-3190 100 μg
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Catalog No. 50-199-3191 Supplier Active Motif Supplier No. 61154
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Description

Mouse Monoclonal Antibody

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter

Specifications

Antigen PCL2
Applications Western Blot
Classification Monoclonal
Clone 3A9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Mtf2
Gene Accession No. Q9Y483
Gene Alias 9230112N11Rik; AA537621; C76717; dJ976O13.2; hPCl2; M96; Metal regulatory transcription factor 2; metal response element binding transcription factor 2; metal response element DNA-binding protein M96; metal response element-binding transcription factor 2; Metal-response element DNA-binding protein M96; Metal-response element-binding transcription factor 2; mPCl2; Mtf2; PCL2; polycomb-like 2; Polycomb-like protein 2; putative DNA binding protein; RGD1304727; RP5-976O13.1; TDRD19A; tudor domain containing 19A; Zinc-regulated factor 1; ZiRF1
Gene Symbols Mtf2
Host Species Mouse
Immunogen This PCL2 antibody was raised against a recombinant protein corresponding to amino acids 103 - 327 of mouse PCL2.
Purification Method Protein G
Quantity 10 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22823
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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