Invitrogen™ PCMT1 Monoclonal Antibody (OTI4A4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527235

Catalog No. PIMA527235

Description

PCMT1 Monoclonal Antibody for Western Blot, IHC (P)

Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.

Specifications

• Antigen: PCMT1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P22061
• Gene Symbols: PCMT1
• Immunogen: Human recombinant protein fragment corresponding to amino acids 60-285 of PCMT1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI4A4
• Conjugate: Unconjugated
• Gene: PCMT1
• Gene Alias: C79501; L-isoaspartyl protein carboxyl methyltransferase; PCM; PCMT1; PIMT; protein carboxyl methyltransferase; protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase; protein-L-isoaspartate (D-aspartate) O-methyltransferase; protein-L-isoaspartate (D-aspartate) O-methyltransferase 1; protein-L-isoaspartate(D-aspartate) O-methyltransferase
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5110
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid