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Invitrogen™ PCMT1 Polyclonal Antibody
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Catalog No. PIPA551872
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100 μL
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PIPA551872 100 μL
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Catalog No. PIPA551872 Supplier Invitrogen™ Supplier No. PA551872
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AKALDVGSGS GILTACFARM VGCTGKVIGI DHIKELVDDS VNNVRKDDPT LLSSGRVQLV VGDGRMGYAE EAPYDAIHVG AAAPVVPQAL IDQLKPGGRL ILPVGPAGGN QMLEQYDKLQ DGSIKMKPLM GVIYVPLTDK EKQWS Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PCMT1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PCMT1
Gene Accession No. P22061, P22062, P23506
Gene Alias C79501; L-isoaspartyl protein carboxyl methyltransferase; PCM; PCMT1; PIMT; protein carboxyl methyltransferase; protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase; protein-L-isoaspartate (D-aspartate) O-methyltransferase; protein-L-isoaspartate (D-aspartate) O-methyltransferase 1; protein-L-isoaspartate(D-aspartate) O-methyltransferase
Gene Symbols PCMT1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PCMT1. Recombinant protein control fragment (Product #RP-96782).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18537, 25604, 5110
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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