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Description
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq]
Specifications
Specifications
| Antigen | PCNA |
| Applications | Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Monoclonal |
| Clone | 1157CT1.1.3 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against synthetic peptide of human PCNA. |
| Dilution | Immunohistochemistry (1:25) Western Blot (1:2000) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.09% sodium azide) |
| Gene Alias | MGC8367 |
| Gene Symbols | PCNA |
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