Invitrogen™ PCNA Recombinant Rabbit Monoclonal Antibody (SAIC-27C-101)

Catalog No.	Quantity
PIMA547908	200 μg

Catalog No. PIMA547908

Supplier: Invitrogen™ MA547908

Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Recognises human PCNA. Preparation: Peptide LVQGSILK derived from PCNA1 (Proliferating cellular nuclear antigen 1) conjugated to KLH. PCNA ins an auxiliary and regulatory protein of DNA polymerase delta involved in control of eukaryotic DNA replication.

PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.

Specifications

• Antigen: PCNA
• Applications: Immunocytochemistry, Mass Spectrometry
• Classification: Recombinant Monoclonal
• Clone: SAIC-27C-101
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% ProClin 300
• Gene: Pcna
• Gene Accession No.: P12004
• Gene Alias: ATLD2; cb16; Cyclin; DNA polymerase delta auxiliary protein; etID36690.10; fa28e03; fb36g03; HGCN8729; hypothetical protein LOC515499; MGC8367; Pcna; pcna protein; Pcna/cyclin; PCNAR; POL30; Proliferating cell nuclear antigen; wu:fa28e03; wu:fb36g03; YBR0811; YBR088C
• Gene Symbols: Pcna
• Host Species: Rabbit
• Immunogen: Peptide LVQGSILK derived from PCNA1 (Proliferating cellular nuclear antigen 1) conjugated to KLH.
• Purification Method: Protein A
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5111
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG λ