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Invitrogen™ PCP4 Monoclonal Antibody (CL5306)
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Catalog No. PIMA535027
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100 μL
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Catalog No. Quantity
PIMA535027 100 μL
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Catalog No. PIMA535027 Supplier Invitrogen™ Supplier No. MA535027
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Description

Mouse Monoclonal Antibody

Immunogen sequence: GAGATNGKDK TSGENDGQKK VQEEFDIDMD APETERAAVA IQSQFRKFQK KK Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 96%.

PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PCP4
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone CL5306
Concentration 0.70 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PCP4
Gene Accession No. P48539, P63054, P63055
Gene Alias brain specific polypeptide PEP19; brain-specific antigen PCP-4; Brain-specific polypeptide PEP-19; Calmodulin regulator protein PCP4; P16Rimb19; PCP4; Pcp-4; Pep19; PEP-19; PEPZ19; Purkinje cell protein 4
Gene Symbols PCP4
Host Species Mouse
Immunogen Recombinant protein fragment of Human PCP4 (Product #RP-88803)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18546, 25510, 5121
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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