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Invitrogen™ PCP4 Polyclonal Antibody
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Catalog No. PA550188
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100 μL
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PA550188 100 μL
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Catalog No. PA550188 Supplier Invitrogen™ Supplier No. PA550188
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total PCP4 protein.

PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PCP4
Applications Western Blot
Classification Polyclonal
Concentration 2.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene PCP4
Gene Accession No. P48539, P63054, P63055
Gene Alias brain specific polypeptide PEP19; brain-specific antigen PCP-4; Brain-specific polypeptide PEP-19; Calmodulin regulator protein PCP4; P16Rimb19; PCP4; Pcp-4; Pep19; PEP-19; PEPZ19; Purkinje cell protein 4
Gene Symbols PCP4
Host Species Rabbit
Immunogen Fusion protein corresponding to a region derived from internal residues of human purkinje cell protein 4.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18546, 25510, 5121
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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