Invitrogen™ PCP4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550188

Catalog No. PA550188

Description

The antibody detects endogenous levels of total PCP4 protein.

PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Specifications

• Antigen: PCP4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCP4
• Gene Alias: brain specific polypeptide PEP19; brain-specific antigen PCP-4; Brain-specific polypeptide PEP-19; Calmodulin regulator protein PCP4; P16Rimb19; PCP4; Pcp-4; Pep19; PEP-19; PEPZ19; Purkinje cell protein 4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18546, 5121
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P48539, P63054
• Gene Symbols: PCP4
• Immunogen: Fusion protein corresponding to a region derived from internal residues of human purkinje cell protein 4.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG