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Invitrogen™ PCP4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA552209
Description
Immunogen sequence: GAGATNGKDK TSGENDGQKK VQEEFDIDMD APETERAAVA IQSQFRKFQK KK Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
Specifications
PCP4 | |
Polyclonal | |
Unconjugated | |
PCP4 | |
brain specific polypeptide PEP19; brain-specific antigen PCP-4; Brain-specific polypeptide PEP-19; Calmodulin regulator protein PCP4; P16Rimb19; PCP4; Pcp-4; Pep19; PEP-19; PEPZ19; Purkinje cell protein 4 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
18546, 5121 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin) | |
0.10 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P48539, P63054 | |
PCP4 | |
Recombinant protein corresponding to Human PCP4. Recombinant protein control fragment (Product #RP-88803). | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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