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Invitrogen™ PCP4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552209

Catalog No. PIPA552209


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Description

Description

Immunogen sequence: GAGATNGKDK TSGENDGQKK VQEEFDIDMD APETERAAVA IQSQFRKFQK KK Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PCP4
Polyclonal
Unconjugated
PCP4
brain specific polypeptide PEP19; brain-specific antigen PCP-4; Brain-specific polypeptide PEP-19; Calmodulin regulator protein PCP4; P16Rimb19; PCP4; Pcp-4; Pep19; PEP-19; PEPZ19; Purkinje cell protein 4
Rabbit
Antigen affinity chromatography
RUO
18546, 5121
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin)
0.10 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
P48539, P63054
PCP4
Recombinant protein corresponding to Human PCP4. Recombinant protein control fragment (Product #RP-88803).
100 μL
Primary
Human, Mouse
Antibody
IgG
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