PCP4 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA550188
The antibody detects endogenous levels of total PCP4 protein.PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer ft.s disease and Huntington ft.s disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
|Fusion protein corresponding to a region derived from internal residues of human purkinje cell protein 4|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 50% glycerol and 0.05% sodium azide; pH 7.3|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok