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  5. Tocris Bioscience™ PD 0332991 isethionate

Tocris Bioscience™ PD 0332991 isethionate
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Catalog No. 478610
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Catalog No. Quantity
47-861-0 10 mg
47-865-0 50 mg
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Catalog No. 47-861-0 Supplier Tocris Bioscience™ Supplier No. 4786/10
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Description

Potent, selective Cdk4/6 inhibitor; brain penetrant

Potent cyclin-dependent kinase 4 (cdk4) and cdk6 inhibitor (IC50 values are 11 nM and 15 nM respectively). Also displays activity at cdk2, cdk5 and cdk9 (IC50 values reported to be 1.6, 1.8 and 0.42-1.1 μM, respectively). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines; blocks growth of intracranial glioblastoma multiforme xenografts in mice. Brain penetrant.

Chemical Identifiers

CAS 827022-33-3
Molecular Formula C26H35N7O6S

Specifications

Assay Percent Range >98%
Quantity 10 mg
Formula Weight 573.66
Molecular Weight (g/mol) 573.669
Chemical Name or Material PD 0332991 isethionate

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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