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PD 0332991 isethionate, Tocris Bioscience™

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Quantity:
10mg
50mg
This item is not returnable. View return policy
827022-33-3
C26H35N7O6S
573.669
LYYVFHRFIJKPOV-UHFFFAOYSA-N
palbociclib isethionate,unii-w1nyl2irdr,pd0332991 isethionate,w1nyl2irdr,pd 0332991 isethionate,palbociclib isethionate usan,6-acetyl-8-cyclopentyl-5-methyl-2-5-piperazin-1-yl pyridin-2-yl amino pyrido 2,3-d pyrimidin-7 8h-one 2-hydroxyethanesulfonate,palbociclib pd0332991 isethionate
11478676
6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;2-hydroxyethanesulfonic acid
CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.C(CS(=O)(=O)O)O
This item is not returnable. View return policy
827022-33-3
C26H35N7O6S
573.669
LYYVFHRFIJKPOV-UHFFFAOYSA-N
palbociclib isethionate,unii-w1nyl2irdr,pd0332991 isethionate,w1nyl2irdr,pd 0332991 isethionate,palbociclib isethionate usan,6-acetyl-8-cyclopentyl-5-methyl-2-5-piperazin-1-yl pyridin-2-yl amino pyrido 2,3-d pyrimidin-7 8h-one 2-hydroxyethanesulfonate,palbociclib pd0332991 isethionate
11478676
6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;2-hydroxyethanesulfonic acid
CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.C(CS(=O)(=O)O)O

Potent, selective Cdk4/6 inhibitor; brain penetrant

Potent cyclin-dependent kinase 4 (cdk4) and cdk6 inhibitor (IC50 values are 11 nM and 15 nM respectively). Also displays activity at cdk2, cdk5 and cdk9 (IC50 values reported to be 1.6, 1.8 and 0.42-1.1 μM, respectively). Induces G1 cell cycle arrest and senescence in retinoblastoma protein (Rb)-proficient cell lines; blocks growth of intracranial glioblastoma multiforme xenografts in mice. Brain penetrant.
Quantity 50mg
Assay Percent Range >98%
Formula Weight 573.66
Chemical Name or Material PD 0332991 isethionate

Recommended Storage : Desiccate at Room Temperature