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Invitrogen™ PD-1 Monoclonal Antibody (J43), Biotin
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Catalog No. PIPA535009
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100 μg
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Catalog No. Quantity
PIPA535009 100 μg
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Catalog No. PIPA535009 Supplier Invitrogen™ Supplier No. PA535009
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Description

Armenian Hamster Monoclonal Antibody

PA5-35009 targets CD279/PD1 in FACS applications and shows reactivity with Mouse samples. The PA5-35009 immunogen is pD-1 cDNA transfectant.

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of 'danger signals' such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
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Specifications

Antigen PD-1
Applications Flow Cytometry
Classification Monoclonal
Clone J43
Concentration 0.1 mg/mL
Conjugate Biotin
Formulation PBS with 4-5mg/mL BSA and 0.02% sodium azide
Gene Pdcd1
Gene Accession No. Q02242
Gene Alias CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Gene Symbols Pdcd1
Host Species Armenian Hamster
Immunogen PD-1 cDNA transfectant.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18566
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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