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Invitrogen™ PD-1 Polyclonal Antibody
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Catalog No. PIPA5119354
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200 μL
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PIPA5119354 200 μL
PIPA5122120 20 μL
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Catalog No. PIPA5119354 Supplier Invitrogen™ Supplier No. PA5119354
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Description

Rabbit Polyclonal Antibody

PD-1 Polyclonal Antibody for Western Blot, IHC (P), ICC/IF

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of 'danger signals' such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
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Specifications

Antigen PD-1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene Pdcd1
Gene Accession No. Q15116
Gene Alias CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Gene Symbols Pdcd1
Host Species Rabbit
Immunogen Recombinant protein Programmed Cell Death Protein 1. The antigen corresponds to amino acid range 41-132 of the target protein.
Purification Method Antigen affinity chromatography, Protein A
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100533201, 301626, 5133
Target Species Human, Rat, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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