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Tocris Bioscience™ PD 173074
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Quantity:
10 mg
50 mg
Description
PD 173074 is a selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ∼100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Also promotes mESC self-renewal, facilitates the conversion of mouse epiblast stem cells to an earlier pluripotency state and inhibits differentiation of miPSCs to cardiomyocytes. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.
Specifications
Specifications
| Quantity | 10 mg |
| Formula Weight | 523.67 |
| Purity | >98% |
| Molecular Weight (g/mol) | 523.682 |
| Chemical Name or Material | PD 173074 |
Safety and Handling
| Recommended Storage | Store at +4°C |
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