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PD 173074, Tocris Bioscience™

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Quantity:
10mg
50mg
This item is not returnable. View return policy
219580-11-7
C28H41N7O3
523.682
DXCUKNQANPLTEJ-UHFFFAOYSA-N
1-tert-butyl-3-2-4-diethylamino butyl amino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, unii-a4tll8634y, 3-tert-butyl-1-2-4-diethylamino butyl amino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, fgf/vegf receptor tyrosine kinase inhibitor, pd173074, 1-tert-butyl-3-2-4-diethylamino butylamino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, 2fgi, 1-t-butyl-3-6-3,5-dimethoxyphenyl-2-4-diethylaminobutylamino-pyrido 2,3-d pyrimidin-7-yl urea, 1-tert-butyl-3-6-3,5-dimethoxy-phenyl-2-4-diethylamino-butylamino-pyrido 2,3-d pyrimidin-7-yl-urea
1401
CHEBI:63448
1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
This item is not returnable. View return policy
219580-11-7
C28H41N7O3
523.682
DXCUKNQANPLTEJ-UHFFFAOYSA-N
1-tert-butyl-3-2-4-diethylamino butyl amino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, unii-a4tll8634y, 3-tert-butyl-1-2-4-diethylamino butyl amino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, fgf/vegf receptor tyrosine kinase inhibitor, pd173074, 1-tert-butyl-3-2-4-diethylamino butylamino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, 2fgi, 1-t-butyl-3-6-3,5-dimethoxyphenyl-2-4-diethylaminobutylamino-pyrido 2,3-d pyrimidin-7-yl urea, 1-tert-butyl-3-6-3,5-dimethoxy-phenyl-2-4-diethylamino-butylamino-pyrido 2,3-d pyrimidin-7-yl-urea
1401
CHEBI:63448
1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C

FGFR1 and -3 inhibitor

Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ∽100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.
Quantity 10mg
Formula Weight 523.67
Percent Purity >98%
Chemical Name or Material PD 173074

Recommended Storage : Store at +4°C