Tocris™ PD 98059

MEK inhibitor

Manufacturer: Tocris™ 1213/50

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Catalog No. 12-135-0R

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For Research Use Only


    Product Type PD 98059
    Inhibitors PD 98059
    Purity >98
    Molecular Weight 267.28
    Quantity 50mg

    Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7µM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™.

    • Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
    • Formula: C16H13NO3
    • CAS Number: 167869-21-8
    • Solubility: Soluble to 25mM in DMSO and to 5mM in ethanol
    • Purity: >98

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